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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 27 |
| Round | Opponent | W / L | Result |
| First Round | Damir Dzumhur | Loss | 5-7, 6-7 (3-7), 1-6 |
| Winston-Salem Open | ||
| Surface: Hard | Date: Aug. 20 - Aug. 26 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jan-Lennard Struff | Loss | 6-7 (2-7), 5-7 |
| Generali Open | ||
| Surface: Clay | Date: Jul. 31 - Aug. 5 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sebastian Ofner | Loss | 3-6, 6-2, 6-7 (3-7) |
| German Tennis Championships 2017 | ||
| Surface: Red Clay | Date: Jul. 24 - Jul. 30 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Andrey Kuznetsov | Loss | 6-3, 5-7, 4-6 |
| SkiStar Swedish Open | ||
| Surface: Clay | Date: Jul. 17 - Jul. 23 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Henri Laaksonen | Loss | 4-6, 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 22 |
| Round | Opponent | W / L | Result |
| First Round | Maxime Hamou | Win | 6-3, 6-2, 6-4 |
| Second Round | Nicolas Kicker | Win | 6-4, 6-4, 6-4 |
| Third Round | Fernando Verdasco | Loss | 2-6, 1-6, 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Adrian Mannarino | Win | 6-4, 7-6 (7-2) |
| Second Round | Dominic Thiem | Loss | 6-7 (4-7), 4-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Thomaz Bellucci | Win | 7-6 (7-2), 4-6, 7-6 (8-6) |
| Second Round | Nicolas Mahut | Win | 5-7, 6-4, 6-4 |
| Third Round | Benoit Paire | Win | 7-5, 0-6, 6-1 |
| Quarterfinals | Alexander Zverev | Win | 3-6, 6-0, 6-4 |
| Semifinals | Dominic Thiem | Loss | 4-6, 4-6 |
| Barcelona Open Banco Sabadell | ||
| Surface: Clay | Date: Apr. 24 - Apr. 30 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Karen Khachanov | Loss | 6-7 (5-7), 6-7 (5-7) |
| Monte-Carlo Rolex Masters | ||
| Surface: Clay | Date: Apr. 16 - Apr. 23 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Viktor Troicki | Win | 6-3, 6-0 |
| Second Round | Joao Sousa | Win | 6-3, 6-3 |
| Third Round | Stan Wawrinka | Win | 6-4, 6-4 |
| Quarterfinals | Lucas Pouille | Loss | 0-6, 6-3, 5-7 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 21 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Benoit Paire | Loss | 5-7, 0-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 27 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Martin Klizan | Win | 7-6 (7-3), 7-6 (7-5) |
| Third Round | Fabio Fognini | Win | 6-1, 6-4 |
| Fourth Round | David Goffin | Win | 6-3, 3-6, 6-3 |
| Quarterfinals | Pablo Carreno Busta | Loss | 1-6, 6-3, 6-7 (4-7) |
| Brasil Open | ||
| Surface: Clay | Date: Feb. 27 - Mar. 6 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Facundo Bagnis | Win | 6-2, 6-2 |
| Quarterfinals | Diego Schwartzman | Win | 5-7, 6-4, 6-4 |
| Semifinals | Pablo Carreno Busta | Win | 6-3, 7-6 (7-2) |
| Final | Albert Ramos-Vinolas | Win | 6-7 (3-7), 6-4, 6-4 |
| Rio Open presented by Claro HDTV | ||
| Surface: Clay | Date: Feb. 20 - Feb. 26 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Arthur De Greef | Loss | 3-6, 6-3, 5-7 |
| Argentina Open | ||
| Surface: Clay | Date: Feb. 13 - Feb. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexandr Dolgopolov | Loss | 3-6, 6-7 (4-7) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 22 |
| Round | Opponent | W / L | Result |
| First Round | Diego Schwartzman | Loss | 3-6, 3-6, 0-6 |
| Apia International Sydney | ||
| Surface: Hard | Date: Jan. 8 - Jan. 14 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nicolas Mahut | Win | 6-4, 2-6, 6-2 |
| Quarterfinals | Gilles Muller | Loss | 6-7 (5-7), 4-6 |
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